myosin-1c; myosin 1 beta; MM1-beta; MM1b (MYO1C)

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Function

myosins are actin-based motor molecules with ATPase activity
unconventional myosins serve in intracellular movements
their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments
involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4- containing vesicles to the plasma membrane
component of the hair cell's (sensory cells of inner ear) adaptation-motor complex
acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells
binds phosphoinositides & links the actin cytoskeleton to cellular membranes
isoform 3 is involved in regulation of transcription associated with transcriptional active ribosomal genes
cooperates with the WICH chromatin-remodeling complex to facilitate transcription
necessary for formation of the first phosphodiester bond during transcription initiation
interacts (via its IQ motifs) with calmodulin
interacts (via its IQ motifs) with CABP1 & CIB1; the interaction with CABP1 & CIB1 is Ca+2-dependent
interacts (via tail domain) with PLEKHB1 (via PH domain); the interaction is not affected by the presence or absence of Ca+2 & calmodulin
interacts with POLR1A & POLR2A
component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A & DDX21 (putative)
interacts with RPS6 & actin

binds directly to large unilamellar vesicles (LUVs) containing phosphatidylinositol 4,5-bisphosphate (PIP2) or inositol 1,4,5-trisphosphate (insP3)
the PIP2-binding site corresponds to a putative PH domain present in its tail domain
contains 2 IQ domains
contains 1 myosin head-like domain

cytoplasm, cell membrane (putative)
cell projection, stereocilium membrane (putative)
colocalizes with CABP1 & CIB1 at cell margin, membrane ruffles & punctate regions on the cell membrane
colocalizes in adipocytes with GLUT4 in actin-based membranes
localizes transiently at cell membrane to region known to be enriched in PIP2
activation of phospholipase C results in its redistribution to the cytoplasm (putative)
isoform 3: nucleus, nucleoplasm, nucleolus, nuclear pore complex
colocalizes with RNA polymerase 2 in the nucleus
colocalizes with RNA polymerase 2 in nucleoli (putative)
in the nucleolus, localized predominantly in dense fibrillar component (DFC) & in granular component
accumulates strongly in dense fibrillar component & granular component during activation of transcription
colocalizes with transcription sites
colocalizes in the granular cortex at the periphery of the nucleolus with RPS6
colocalizes in nucleoplasm with RPS6 & actin that are in contact with RNP particles
colocalizes with RPS6 at the nuclear pore level

gene prediction based on EST data