bromodomain adjacent to zinc finger domain protein 1B (Williams-Beuren syndrome chromosome region 9 protein, Williams syndrome transcription factor, hWALP2, BAZ1B, WBSC10, WBSCR9, WSTF)

Function

• forms a chromatin remodeling complex that mobilizes nucleosomes & reconfigures irregular chromatin to a regular nucleosomal array structure
• interacts with ISWI (imitation SWI protein) to form the WSTF-ISWI chromatin remodeling complex (WICH)

Structure

• belongs to the WAL family
• contains 1 bromo domain
  • contains 1 DDT domain
  • contains 1 PHD-type zinc finger
  • contains 1 WAC domain

Compartment

• nucleus
• accumulates in pericentromeric heterochromatin during replication

Alternative splicing

named isoforms=2

Expression

• ubiquitously expressed, including heart, brain, placenta, skeletal muscle, ovary

Pathology

• defects in BAZ1B associated with Williams-Beuren syndrome

More general terms

• zinc finger protein
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/194050
• OMIM: https://mirror.omim.org/entry/605681
• UniProt: http://www.uniprot.org/uniprot/Q9UIG0.html