pleckstrin homology domain-containing family B member 1; PH domain-containing family B member 1; evectin-1; PH domain-containing protein in retina 1; PHRET1; pleckstrin homology domain retinal protein 1 (PLEKHB1, EVT1, KPL1, PHR1, PHRET1)

Function

• required for proper localization of retina-geniculate projections but not for eye-specific segregation (putative)
• homodimer
• interacts (via PH domain) with MYO1C
• interacts (via PH domain) with MYO7A (putative)
• binds transducins

Structure

contains 1 PH domain

Compartment

• membrane. cytoplasm (putative)
• localizes to the apical juxta-nuclear Golgi region of the cytoplasm (putative)
• membrane-associated
• highly expressed in the outer segments of photoreceptor cells, both in rods & cones

Alternative splicing

named isoforms=4

Expression

• highly expressed in retina & brain
• levels are very low or not detectable in all other tissues tested

More general terms

• pleckstrin homology domain containing family

Additional terms

• pleckstrin homology [PH] domain
• pleckstrin; platelet p47 protein (PLEK P47)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=58473
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:58473
• OMIM: https://mirror.omim.org/entry/607651
• UniProt: http://www.uniprot.org/uniprot/Q9UF11.html