Ca+2 & integrin-binding protein 1; CIB; Ca+2- & integrin-binding protein; CIBP; calmyrin; DNA-PKcs-interacting protein; kinase-interacting protein; KIP; SNK-interacting protein 2-28; SIP2-28 (CIB1, CIB, KIP, PRKDCIP)

^[1]

Function

may convert the inactive conformation of integrin alpha-2b/beta-3 to an active form through binding tothe integrin cytoplasmic domain
induces cell migration & spreading mediated through integrin (possibly via focal adhesion complexes)
negative regulator of stress activated MAP kinase (MAPK) signaling pathways
may play a role in regulation of apoptosis
interacts with & up-regulates PTK2 activity
down regulates inositol 1,4,5-trisphosphate receptor- dependent Ca+2 signaling
interacts with the heterodimeric integrin alpha-2b/beta-3
interacts with the protein kinases PLK2/SNK & with the region immediately upstream of the kinase domain of DNA-PK
interacts with PSEN2
interacts with MYO1C (putative)
interacts (via C-terminus) with F8
interacts with NBR1 (via C-terminus)
interacts with FEZ1 (via C-terminus)
interacts with UBR5 (via C-terminus); the interaction is sensitive to DNA damage, & may target CIB1 for ubiquitin- mediated degradation
interacts with IFI6
interacts with BCL2
interacts with TAS1R2 (via C-terminus); this interaction is independent of myristoylation
interacts with ITPR3 (Ca+2 dependent)
interacts with PTK2
interacts with MAP3K5, inhibiting MAP3K5 activation by phosphorylation, & its subsequent interaction with TRAF2