inositol

Introduction

1,2,3,4,5,6-hexahydroxycyclohexane; a member of the vitamin B complex necessary for growth of yeast & mice. Absence from the diet causes alopecia & dermatitis in mice. It occurs in a number of stereo-isomeric forms: cis-, epi-, allo-, neo-, myo-, muco-, chiro-, & scyllo-inositols. The most abundant naturally occurring isomer is myo-inositol (usually meant by 'inositol').

Pharmacokinetics

• crosses the blood brain barrier
• metabolized to glucose

Mechanism of action

• inositol competes with phosphoinositides for interaction of Abeta, thus reduces formation o A-beta oligomers (ADOLS)

More general terms

• sugar alcohol
• lipotropic

More specific terms

• inositol phosphate
• scyllo-inositol; cocositol; quercinitol; 1,3,5/2,4,6-hexahydroxycyclohexane (AZD-103)

Component of

• inositol/nicotinic acid
• folic acid/inositol
• cysteine/inositol/methionine/propionate/urea
• choline/inositol
• ascorbate/bioflavonoid/choline bitartrate/cobalamin/inositol/nicotinamide/pantothenate/pyridoxine/riboflavin/thiamine
• cysteine/inositol/methionine/urea

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=892