Tissue factor pathway inhibitor; TFPI; extrinsic pathway inhibitor; EPI; lipoprotein-associated coagulation inhibitor; LACI (TFPI LACI TFPI1)

Function

• inhibits factor X (factor Xa) directly
• inhibits factor VIIa/tissue factor activity (factor Xa- dependent), presumably by forming a quaternary factor Xa/LACI/factor VIIa/TF complex
• has antithrombotic action
• can associate with lipoproteins in plasma

Structure

• O-glycosylated
• contains 3 BPTI/Kunitz inhibitor domains
  • 1st domain interacts with factor VIIa & TF
  • 2nd domain interacts with factor Xa

Compartment

secreted

Alternative splicing

named isoforms=2

Expression

mostly in endothelial cells

More general terms

• serine protease inhibitor; serpin
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7035
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7035
• OMIM: https://mirror.omim.org/entry/152310
• UniProt: http://www.uniprot.org/uniprot/P10646.html