E3 ubiquitin-protein ligase UBR5; E3 ubiquitin-protein ligase, HECT domain-containing 1; hyperplastic discs protein homolog; hHYD; Progestin-induced protein (UBR5, EDD, EDD1, HYD, KIAA0896)

Function

• E3 ubiquitin-protein ligase, component of the N-end rule pathway
• recognizes & binds to proteins bearing specific amino-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination & subsequent degradation (putative)
• may be involved in maturation &/or transcriptional regulation of mRNA
• may play a role in control of cell cycle progression
• may have tumor suppressor function
• regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response
• role in extraembryonic development
• protein modification; protein ubiquitination
• phosphorylated upon DNA damage, probably by ATM or ATR
• binds TOPBP1

Structure

• contains 1 HECT domain
• contains 1 PABC domain
• contains 1 UBR-type Zn+2 finger
• a Cys is required for ubiquitin-thioester formation

Compartment

nucleus

Expression

• widely expressed
• most abundant in testis
• expressed at high levels in brain, pituitary & kidney

More general terms

• E3 ubiquitin ligase
• nuclear protein
• zinc finger protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51366
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:51366
• OMIM: https://mirror.omim.org/entry/608413
• UniProt: http://www.uniprot.org/uniprot/O95071.html