topoisomerase-2

Function

• control of topological states of DNA by transient breakage & subsequent rejoining of DNA strands
• topoisomerase 2 makes double-strand breaks
• DNA cleavage by topoisomerase 2 induces reversible, protein- associated fragments of > 600 kb
• reversible cleavage into > 600 kb fragment appears to be a signal for the engagement of apoptosis
• further cleavage leads to 300 & 50 kb fragments.
• formation of 50 kb fragments is irreversible
• eukaryotic topoisomerase 1 & topoisomerase 2 can relax both negative & positive supercoils, whereas prokaryotic enzymes relax only negative supercoils

Compartment

• topoisomerase 2 occurs with a periodicity of 300 kbp along chromatin, associated with the nuclear scaffold

More general terms

• topoisomerase
• oligomerizing protein
• pro apoptotic protein

More specific terms

• DNA topoisomerase-2 alpha (TOP2A)
• topoisomerase-2 beta (TOP2B)

Database

• OMIM: https://mirror.omim.org/entry/126430