DNA topoisomerase-2 alpha (TOP2A)
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Function
- control of topological states of DNA by transient breakage & subsequent rejoining of DNA strands
- topoisomerase 2 makes double-strand breaks
- specifically inhibited by the intercalating agent amsacrine
- phosphorylation has no effect on catalytic activity
- ATP-dependent breakage, passage & rejoining of double-stranded DNA
- eukaryotic topoisomerase 1 & topoisomerase 2 can relax both negative & positive supercoils, whereas prokaryotic enzymes relax only negative supercoils
Structure
- homodimer
- interacts with COPS5
- belongs to the type 2 topoisomerase family
Compartment
- cytoplasm. nucleus, nucleoplasm
- generally located in the nucleoplasm
Alternative splicing
named isoforms=4
More general terms
References
- ↑ Martin SJ, Green DR, Cotter TG. Dicing with death: dissecting the components of the apoptosis machinery. Trends Biochem Sci. 1994 Jan;19(1):26-30. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8140617
- ↑ Beere HM, Chresta CM, Alejo-Herberg A, Skladanowski A, Dive C, Larsen AK, Hickman JA. Investigation of the mechanism of higher order chromatin fragmentation observed in drug-induced apoptosis. Mol Pharmacol. 1995 May;47(5):986-96. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7746285
- ↑ UniProt http://www.uniprot.org/uniprot/P11388.html