coagulation factor VIII; antihemophilic factor; AHF; procoagulant component; contains: factor VIIIa heavy chain, 200 kD & 92 isoforms; factor VIII B chain; factor VIIIa light chain (F8, F8C)

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Function

Structure

Compartment

secreted, extracellular space

Expression

Pathology

deficiency associated with hemophilia A

Pharmacology

see antihemophilic factor

Laboratory

More general terms

More specific terms

Additional terms

Component of

References

  1. Walker FJ, Fay PJ. Regulation of blood coagulation by the protein C system. FASEB J. 1992 May;6(8):2561-7. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1317308
  2. Andrews BS. Is the WKS motif the tissue-factor binding site for coagulation factor VII? Trends Biochem Sci. 1991 Jan;16(1):31-6. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2053135
  3. Medical Knowledge Self Assessment Program (MKSAP) 11, 18, American College of Physicians, Philadelphia 1998, 2018.
  4. Wikipedia: Factor VIII http://en.wikipedia.org/wiki/Factor_VIII
  5. UniProt http://www.uniprot.org/uniprot/P00451.html
  6. HAMsters; Note: factor VIII mutation db http://hadb.org.uk/WebPages/main/main.htm
  7. GeneReviews http://www.ncbi.nlm.nih.gov/sites/genetests/lab/gene/F8
  8. SeattleSNPs http://pga.gs.washington.edu/data/f8/

Database