coagulation factor VIII alloantibody

Introduction

Alloantibody to factor VIII occurs in 20-25% of patients with severe hemophilia A transfused with factor VIII.

Laboratory

• prolonged aPTT, NOT corrected with addition of normal plasma
• coagulation factor VIII inhibitor in plasma

Management

• immunosuppressive therapy
• acute bleeding
  • porcine factor VIII (generally less reactive with anti-human factor VIII)
  • prothrombin complex concentrate
  • recombinant factor VIIa concentrate
  • plasmapheresis

More general terms

• alloantibody
• coagulation factor VIII antibody

Additional terms

• coagulation factor VIII autoantibody (acquired hemophilia)
• coagulation factor VIII inhibitor in plasma
• coagulation factor VIII; antihemophilic factor; AHF; procoagulant component; contains: factor VIIIa heavy chain, 200 kD & 92 isoforms; factor VIII B chain; factor VIIIa light chain (F8, F8C)