coagulation factor VIII autoantibody (acquired hemophilia)

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Etiology

Epidemiology

  • postpartum: occurs most often after birth of 1st child

Clinical manifestations

Laboratory

* an incomplete correction consistent with autoantibody (from 95 to 45 seconds)[5]

Differential diagnosis

Management

More general terms

Additional terms

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Medical Knowledge Self Assessment Program (MKSAP) 11, 16, 17, 18, 19. American College of Physicians, Philadelphia 1998, 2012, 2015. 2018, 2022.
  2. Schiller G, in: UCLA Intensive Course in Geriatric Medicine & Board Review, Marina Del Ray, CA, Sept 12-15, 2001
  3. Barnett B, Kruse-Jarres R, Leissinger CA. Current management of acquired factor VIII inhibitors. Curr Opin Hematol. 2008 Sep;15(5):451-5. PMID: https://www.ncbi.nlm.nih.gov/pubmed/18695367
  4. Gibson CJ, Berliner N, Miller AL et al A Bruising Loss. N Engl J Med 2016; 375:76-81. July 7, 201 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/27406351 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMcps1500127
  5. 5.0 5.1 Geriatric Review Syllabus, 10th edition (GRS10) Harper GM, Lyons WL, Potter JF (eds) American Geriatrics Society, 2019
  6. Franchini M, Vaglio S, Marano G et al Acquired hemophilia A: a review of recent data and new therapeutic options. Hematology. 2017 Oct;22(9):514-520. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/28441921
  7. Kruse-Jarres R, Kempton CL, Baudo F er al Acquired hemophilia A: Updated review of evidence and treatment guidance. Am J Hematol. 2017 Jul;92(7):695-705. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/28470674 Free Article
  8. 8.0 8.1 8.2 8.3 NEJM Knowledge+ Hematology

Patient information

coagulation factor VIII autoantibody (acquired hemophilia) patient information