desmopressin (deamino-arginine vasopressin, dDAVP, dDVP, Noctiva, Stimate, Minirin)

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Indications

Contraindications

Pregnancy category: B

Safety in lactation: ?

Dosage

Injection: 4 ug/mL (1 mL)

DDAVP nasal spray:

  • 10 ug/metered dose
  • 100 ug/mL (100 ug = 400 IU), 5 mL

Nasal spray (Stimate):

  • 1 spray/nostril (300 ug total)
  • for individuals < 50 kg, use 150 ug total or less
  • 10 & 150 ug/spray (1.5 mg/mL, 2.5 mL)

DDAVP tablets: 0.1 & 0.2 mg

Pharmacokinetics

  • elimination: liver, kidney

Adverse effects

Laboratory

Mechanism of action

More general terms

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  3. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  4. 4.0 4.1 FDA MedWatch http://www.fda.gov/medwatch/safety/2007/safety07.htm#Desmopressin
  5. 5.0 5.1 5.2 Prescriber's Letter 15(1): 2008 New Precautions for Use of Desmopressin Acetate (DDAVP, DDVP, Minirin, and Stimate) Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=240112&pb=PRL (subscription needed) http://www.prescribersletter.com
  6. 6.0 6.1 Deprecated Reference
  7. 7.0 7.1 7.2 7.3 FDA News Release. March 3, 2017 FDA approves first treatment for frequent urination at night due to overproduction of urine https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm544877.htm
    Fralick M, Kesselheim AS. FDA Approval of Desmopressin for Nocturia. JAMA. 2017;317(20):2059-2060 Free full text Free PMC Article http://jamanetwork.com/journals/jama/article-abstract/2617966
  8. 8.0 8.1 8.2 8.3 Geriatric Review Syllabus, 10th edition (GRS10) Harper GM, Lyons WL, Potter JF (eds) American Geriatrics Society, 2019
  9. 9.0 9.1 Feldman EA, Meola G, Zyck S et al. Retrospective assessment of desmopressin effectiveness and safety in patients with antiplatelet-associated intracranial hemorrhage. Crit Care Med 2019 Sep 24; PMID: https://www.ncbi.nlm.nih.gov/pubmed/31567345
  10. 10.0 10.1 10.2 Connell NT, James PD, Brignardello-Petersen R et al. ASH ISTH NHF WFH 2021 guidelines on the management of von Willebrand disease. Blood Adv 2021 Jan 12; 5:301 PMID: https://www.ncbi.nlm.nih.gov/pubmed/33496750 PMCID: PMC7839375 Free PMC article https://ashpublications.org/bloodadvances/article/5/1/301/474884/ASH-ISTH-NHF-WFH-2021-guidelines-on-the-management
  11. NOCTIVA (desmopressin acetate) nasal spray, for intranasal use. Prescribing Information http://www.accessdata.fda.gov/drugsatfda_docs/label/2017/201656lbl.pdf