polyuria
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Introduction
Loosely defined as a 24 hour urinary output of > 3 liters.
Etiology
- diabetes insipidus
- central (vasopressin-responsive)
- nephrogenic
- acquired renal tubulointerstitial disease
- drugs or toxins
- congenital syndromes
- solute diuresis
- natriuretic syndromes
- salt-losing nephritis
- diuretic phase of acute tubular necrosis (ATN)
- diuretics
- primary polydipsia
- psychogenic
- hypothalamic disease
- pharmaceutical agents
Laboratory
- plasma copeptin* distinguishes diabetes insipidus from primary polydipsia[4]
* fragment of the arginine vasopressin prohormone
More general terms
Additional terms
References
- ↑ Harrison's Principles of Internal Medicine, 13th ed. Companion Handbook, Isselbacher et al (eds), McGraw-Hill Inc. NY, 1995, pg 829-39
- ↑ Guide to Physical Examination & History Taking, 4th edition, Bates B, JB Lippincott, Philadelphia, 1987
- ↑ Harrison's Principles of Internal Medicine, 13th ed. Isselbacher et al (eds), McGraw-Hill Inc. NY, 1994, pg 239
- ↑ 4.0 4.1 Fenske W, Refardt J, Chifu I et al. A copeptin-based approach in the diagnosis of diabetes insipidus. N Engl J Med 2018 Aug 2; 379:428. PMID: https://www.ncbi.nlm.nih.gov/pubmed/30067922 https://www.nejm.org/doi/10.1056/NEJMoa1803760
Rosen CJ, Ingelfinger JR. A reliable diagnostic test for hypotonic polyuria. N Engl J Med 2018 Aug 2; 379:483. PMID: https://www.ncbi.nlm.nih.gov/pubmed/30067935 https://www.nejm.org/doi/10.1056/NEJMe1808195