copeptin in serum

^[1]^[2]^[3]

Clinical significance

assessing prognosis in heart failure
- higher serum copeptin levels predict cardiovascular mortality & all cause mortality in patients with heart failure^[1]
- adding serum copeptin to a model that already includes serum NT-proBNP modestly improves discrimination (increases C-index from 0.74 to 0.76)
used in the CoRisk Score for assessing prognosis in ischemic stroke^[2]
- median copeptin value in patients with ischemic stroke: 14.2 pmol/L
plasma copeptin* distinguishes diabetes insipidus from primary polydipsia^[2]
- activity is low in diabetes insipidus
- antigen is also low in central diabetes insipidus

* fragment of the arginine vasopressin prohormone (test not widely available)

↑ ^1.0 ^1.1 Alehagen U et al. Association of copeptin and N-terminal proBNP concentrations with risk of cardiovascular death in older patients with symptoms of heart failure. JAMA 2011 May 25; 305:2088. PMID: https://www.ncbi.nlm.nih.gov/pubmed/21610241
↑ ^2.0 ^2.1 ^2.2 Fenske W, Refardt J, Chifu I et al. A copeptin-based approach in the diagnosis of diabetes insipidus. N Engl J Med 2018 Aug 2; 379:428. PMID: https://www.ncbi.nlm.nih.gov/pubmed/30067922 https://www.nejm.org/doi/10.1056/NEJMoa1803760
Rosen CJ, Ingelfinger JR. A reliable diagnostic test for hypotonic polyuria. N Engl J Med 2018 Aug 2; 379:483. PMID: https://www.ncbi.nlm.nih.gov/pubmed/30067935 https://www.nejm.org/doi/10.1056/NEJMe1808195
↑ De Marchis GM, Dankowski T, Konig IR et al. A novel biomarker-based prognostic score in acute ischemic stroke: The CoRisk score. Neurology 2019 Mar 26; 92:e1517. PMID: https://www.ncbi.nlm.nih.gov/pubmed/30824558 https://n.neurology.org/content/92/13/e1517