antihemophilic factor (coagulation factor VIII, AHF-M, Hemofil, Humate-P, Monoclate-P)

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Introduction

Tradenames: AHF-M, Hemofil, Humate-P, Monoclate-P, Advate*

Indications

Contraindications

Pregnancy category: C)

Safety in lactation: ?

Dosage

AHF units = body weight (kg) x desired AHF increase (%) x 0.5

* Advate (Baxter) is free of plasma & albumin[5]

Pharmacokinetics

Adverse effects

More general terms

More specific terms

Additional terms

References

  1. Walker FJ, Fay PJ. Regulation of blood coagulation by the protein C system. FASEB J. 1992 May;6(8):2561-7. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1317308
  2. Andrews BS. Is the WKS motif the tissue-factor binding site for coagulation factor VII? Trends Biochem Sci. 1991 Jan;16(1):31-6. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2053135
  3. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  4. Medical Knowledge Self Assessment Program (MKSAP) 11, 18. American College of Physicians, Philadelphia 1998, 2018,
  5. 5.0 5.1 Prescriber's Letter 11(2):suppl 2004
  6. Department of Veterans Affairs, VA National Formulary