ceruloplasmin; ferroxidase (CP)

Function

• oxidizes Fe+2 to Fe+3 without releasing oxygen radicals
• essential for transferrin binding of iron
• binds copper (6-7 atoms per molecule)
  • but not a transport protein for copper
• involved in iron transport across the cell membrane

4 Fe+2 + 4 H+ + O2 = 4 Fe+3 + 2 H2O

Cofactor: binds 6 copper ions per monomer

Structure

• glycoprotein
• belongs to the multicopper oxidase family
• contains 3 F5/8 type A domains
• contains 6 plastocyanin-like domains

Compartment

secreted

Expression

• expressed by the liver & secreted into plasma

Pathology

• defects in CP are the cause of aceruloplasminemia
• ceruloplasmin levels are decreased in Wilson's disease
  • copper cannot be incorporated into ceruloplasmin in liver due to a defect in copper transporting ATPase-2

Notes

• blue protein

More general terms

• oxidoreductase
• metalloprotein
• alpha 2 globulin
• glycoprotein
• acute phase protein
• phosphoprotein

Additional terms

• ceruloplasmin in serum

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1356
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1356
• OMIM: https://mirror.omim.org/entry/117700
• OMIM: https://mirror.omim.org/entry/604290
• UniProt: http://www.uniprot.org/uniprot/P00450.html