ceruloplasmin in serum
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Indications
Reference interval
- Adults: 21-53 mg/dL.
Principle
The Beckman Array Protein System, in conjunction with the Ceruloplasmin Reagent Test Kit, is intended for in vitro diagnostic quantitation of Ceruloplasmin in biological fluids by rate nephelometry.
Ceruloplasmin is a blue copper protein found in serum associated with alpha globulin. Although variations in its concentration are found in various pathologic conditions, its exact metabolic role is unknown.
It is a late acute phase reactant; it is the principle copper-containing protein of plasma.
Increases
- pregnancy
- subacute or chronic infection
- myocardial infarction
- hepatic cirrhosis
- hyperthyroidism
- aplastic anemia or refractory anemia
- Hodgkin's disease
- acute leukemia
- estrogen therapy
Decreases
- Wilson's disease
- occasionally in unaffected relatives of patients with Wilson's disease
- neonatal period
- nephrotic syndrome
- occasionally in:
- Kwashiorkor
- tropical sprue
- certain infants with a syndrome of anemia & hypoproteinemia
Specimen
No special patient preparation is required. 200 uL of serum. Store sample in freezer until ready for assay. Highly lipemic samples may result in inaccurate determination & should be redrawn on a fasting patient.
More general terms
Additional terms
References
- ↑ Beckman Array Protein System Operating Manual.
- ↑ Tietz, Norbert W: Textbook of Clinical Chemistry, W.B. Saunders Co., Philadelphia, PA; pp. 595-596, 1986.
- ↑ Bauer, John D., Ackerman, Phillip G, Toro, Gelson: Clinical Laboratory Methods, 8th Edition, The C.V. Mosby Co., St. Louis, MO; p. 477-478.
- ↑ Panel of 3 tests Laboratory Test Directory ARUP: http://www.aruplab.com/guides/ug/tests/0020598.jsp
- ↑ Ceruloplasmin Laboratory Test Directory ARUP: http://www.aruplab.com/guides/ug/tests/0050160.jsp