copper transporting ATPase-2; Cu+2-transporting ATPase beta polypeptide; copper pump-2; WIlson's disease-associated protein (ATP7B, PWD, WC1, WND)

From Aaushi
Jump to navigation Jump to search

Function

  • role in the export of copper out of the cells, efflux of hepatic copper into the bile
  • isoform 1 may be proteolytically cleaved at the N-terminus to produce the WND/140 kD form
  • interacts with COMMD1/MURR1
ATP + H2O + Cu+2(In) <--> ADP + phosphate + Cu+2(out)

Structure

Compartment

Alternative splicing

named isoforms=4

Expression

  • most abundant in liver & kidney
  • also found in brain
  • isoform 2 is expressed in brain but not in liver
  • cleaved form WND/140 kD is found in liver cell lines & other tissues

Pathology

More general terms

Additional terms

References

Database