inositol 1,4,5-trisphosphate receptor type 3; IP3 receptor-3; type 3 inositol 1,4,5-trisphosphate receptor; type 3 insP3 receptor; IP3 receptor isoform 3; insP3R3 (ITPR3)

Function

• receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular Ca+2
• phosphorylated on Tyr (putative)
• interacts with OPRS1, TRPC1, TRPC3 & TRPC4 (putative)

Structure

• homotetramer.
• contains a Ca+2 channel in its C-terminal extremity
• its large N-terminal cytoplasmic region has the ligand- binding site in the N-terminus & modulatory sites in the middle portion immediately upstream of the channel region
• belongs to the insP3 receptor family
• contains 5 MIR domains

Compartment

endoplasmic reticulum membrane

Expression

• expressed in intestinal crypt & villus epithelial cells

More general terms

• transmembrane 6 protein
• inositol triphosphate [IP3] receptor P400 (ITPR, IP3-R)
• phosphoprotein

Additional terms

• inositol-1,4,5-triphosphate (IP3)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3710
• OMIM: https://mirror.omim.org/entry/147267
• UniProt: http://www.uniprot.org/uniprot/Q14573.html