short transient receptor potential channel 3 (transient receptor potential cation channel subfamily C member 3, TrpC3, Htrp3, TRP3)

Function

• receptor-activated non-selective Ca+2 permeant cation channel
• operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors (putative)
• activated by diacylglycerol independent of protein kinase C & by inositol-1,4,5-triphosphate receptors (ITPR) with bound IP3
• activated by internal Ca+2 store depletion (putative)
• interacts with TRPC1, ITPR

Structure

• belongs to the transient receptor family, STrpC subfamily
• contains 4 ANK repeats

Compartment

membrane

Expression

• expressed in brain >> ovary, colon, small intestine, lung, prostate, placenta, testis

More general terms

• transient receptor potential cation channel subfamily C (TRPC)
• transmembrane 6 protein

Database

• OMIM: https://mirror.omim.org/entry/602345
• UniProt: http://www.uniprot.org/uniprot/Q13507.html