inositol triphosphate [IP3] receptor P400 (ITPR, IP3-R)

From Aaushi
Jump to navigation Jump to search

Introduction

Three distinct genes encode 3 similar IP3-receptors, with 69% sequence homology.

Function

Structure

homologous to ryanodine receptor

Alternative splicing

Expression

  • present in all tissues tested
  • highest levels in cortex & cerebellum

More general terms

More specific terms

Additional terms

References

  1. Ferris et al Proc Natl Acad Sci U S A 1990 Mar;87(6):2147-51
  2. Mignery GA, Sdhof TC. The ligand binding site and transduction mechanism in the inositol-1,4,5-triphosphate receptor. EMBO J. 1990 Dec;9(12):3893-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2174351
  3. Yamamoto H, Maeda N, Niinobe M, Miyamoto E, Mikoshiba K. Phosphorylation of P400 protein by cyclic AMP-dependent protein kinase and Ca2+/calmodulin-dependent protein kinase II. J Neurochem. 1989 Sep;53(3):917-23. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2547906
  4. Miyawaki A, Furuichi T, Maeda N, Mikoshiba K. Expressed cerebellar-type inositol 1,4,5-trisphosphate receptor, P400, has calcium release activity in a fibroblast L cell line. Neuron. 1990 Jul;5(1):11-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2164403-8
  5. Taylor CW, Marshall IC. Calcium and inositol 1,4,5-trisphosphate receptors: a complex relationship. Trends Biochem Sci. 1992 Oct;17(10):403-7. Review. Erratum in: Trends Biochem Sci 1992 Dec;17(12):493. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1333657
  6. Sheng M. Molecular organization of the postsynaptic specialization. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7058-61. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11416187