ryanodine receptor (RyR)

Function

• Ca+2 channel
• release Ca+2 from intracellular stores
• signal transduction
• excitation-contraction
• excitation-secretion coupling
• hysiological modulators:
  • Ca+2
  • kinases
  • phosphatases
  • redox state
  • energy charge, ATP

Structure

tetramer

Expression

• RyR1 is expressed mainly skeletal muscle
• RyR2 is expressed in cardiac muscle
• RyR3 is expressed in nervous system

Pharmacology

• pharmacological regulators:
  • caffeine
  • dantrolene
  • ruthenium red
  • heavy metals
  • ryanodine

More general terms

• transmembrane 12 protein
• oligomerizing protein
• ionotropic receptor
• Ca+2 channel

More specific terms

• ryanodine receptor 1; RYR-1; RyR1; skeletal muscle-type ryanodine receptor; skeletal muscle Ca+2 release channel (RYR1, RYDR)
• ryanodine receptor 2; RYR-2; RyR2; hRYR-2; cardiac muscle-type ryanodine receptor; cardiac muscle ryanodine receptor-Ca+2 release channel (RYR2)
• Ryanodine receptor 3; RYR-3; RyR3; brain-type ryanodine receptor; brain ryanodine receptor-Ca+2 release channel (RYR3, HBRR)

Additional terms

• ryanodine