inositol 1,4,5-trisphosphate receptor type 2; IP3 receptor-2; type 2 inositol 1,4,5-trisphosphate receptor; type 2 insP3 receptor; IP3 receptor isoform 2; insP3R2 (ITPR2)

Function

• receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular Ca+2
• Ca+2 appears to inhibit ligand binding to the receptor, probably by interacting with a distinct Ca+2-binding protein which then inhibits the receptor
• phosphorylated on tyrosine residues (putative)

Structure

• homotetramer (putative)
• contains a Ca+2 channel in its C-terminal extremity
• its large N-terminal cytoplasmic region has the ligand- binding site in the N-terminus & modulatory sites in the middle portion immediately upstream of the channel region
• belongs to the insP3 receptor family
• contains 5 MIR domains

Compartment

endoplasmic reticulum membrane

Alternative splicing

named isoforms=2

Expression

• the short isoform is found in skeletal muscle & heart

More general terms

• inositol triphosphate [IP3] receptor P400 (ITPR, IP3-R)
• phosphoprotein

Additional terms

• inositol-1,4,5-triphosphate (IP3)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3709
• OMIM: https://mirror.omim.org/entry/600144
• UniProt: http://www.uniprot.org/uniprot/Q14571.html