sigma non-opioid intracellular receptor 1; aging-associated gene 8 protein; SR31747-binding protein; SR-BP; sigma 1-type opioid receptor; SIG-1R; sigma1-receptor; sigma1R; hsigmaR1 (SIGMAR1, OPRS1, SRBP, AAG8 S1R)
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Function
- lipid transport from endoplasmic reticulum
- involved in a wide array of cellular functions via regulating biogenesis of lipid microdomains at the plasma membrane
- regulation of different receptors
- regulates ion channels, i.e. K+ channel
- may modulate neurotransmitter release
- Ca+2 signaling
- in conjunction with ANK2 modulates ITP3R-dependent Ca+ efflux at the endoplasmic reticulum
- cell proliferation, survival & cell death
- originally identified for its ability to bind various psychoactive drugs
- involved in learning processes, memory & mood alteration
- depletion of OPRS1 by RNAi inhibits growth & survival signaling cascades & induces cell death; the OSPR1 antagonist rimcazole produces the same effect
- regulation of cytokine production through its interaction with IRE1[3]
Structure
belongs to the ERG2 family
Compartment
- nucleus, nuclear inner membrane, nuclear outer membrane
- endoplasmic reticulum, endoplasmic reticulum membrane
- lipid droplet, cell junction, cell membrane
- targeted to lipid droplets, cholesterol & galactosylceramide- enriched domains of the endoplasmic reticulum
- enriched at cell-cell communication regions, growth cone & postsynaptic structures
- localization modulated by ligand-binding
Alternative splicing
named isoforms=5
Expression
- widely expressed
- especially in liver, colon, prostate, placenta, small intestine, heart, pancreas
- expressed in the retina by retinal pigment epithelial cells
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q99720.html
- ↑ Wikipedia; Note: sigma-1 receptor entry http://en.wikipedia.org/wiki/sigma_1_receptor
- ↑ 3.0 3.1 Lenze EJ, Mattar C, Zorumski CF et al Fluvoxamine vs Placebo and Clinical Deterioration in Outpatients With Symptomatic COVID-19A Randomized Clinical Trial. JAMA. Published online November 12, 2020. PMID: https://www.ncbi.nlm.nih.gov/pubmed/33180097 https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2020.22760