brain-derived neurotrophic factor; BDNF; abrineurin (BDNF)
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Function
- neurotrophic for dopaminergic neurons of substantia nigra, sensory neurons of nodose ganglion, retinal ganglion cells & septal cholinergic cells
- along withother neurotrophins, binds to & activates gp145trkB
- role in long-term potentiation
- during development, promotes survival & differentiation of selected neuronal populations of the PNS & CNS
- role in axonal growth, pathfinding & in modulation of dendritic growth & morphology
- major regulator of synaptic transmission & plasticity at adult synapses in many regions of the CNS
- versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including
- long-term potentiation (LTP)
- long-term depression (LTD)
- certain forms of short-term synaptic plasticity
- homeostatic regulation of intrinsic neuronal excitability
- converted into mature BDNF by plasmin (PLG) (putative)
- binds to NTRK2/TRKB
- implicated in regulation of food intake & body weight in rodents
Structure
- the propeptide is N-glycosylated & glycosulfated
- monomers & homodimers
- belongs to the NGF-beta family
Compartment
Alternative splicing
- named isoforms=5
- also alternative promoter usage:
- 2 types of transcripts are produced
- non-coding transcripts (antisense, opposite strand, 8 exons)
- coding transcripts (11 exons)
- brain BDNF & anti-BDNF transcripts form dsRNA duplexes
Expression
- expressed in brain
- highly expressed in hippocampus, amygdala, cerebral cortex & cerebellum
- also expressed in heart, lung, skeletal muscle, testis, prostate & placenta
Polymorphism
- variations in BDNF are associated with susceptibility to bulimia nervosa 2
- defects in BDNF are a cause of congenital central hypoventilation syndrome (Ondine curse)
More general terms
Additional terms
References
- ↑ Hohn A, Leibrock J, Bailey K, Barde YA. Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family. Nature. 1990 Mar 22;344(6264):339-41. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2314473
- ↑ Hyman C et al BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra. Nature 350:230 1991 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2005978
- ↑ Journal Watch 23(6):48, 2003 Egan MF et al Cell 112:257, 2003
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=627
- ↑ UniProt http://www.uniprot.org/uniprot/P23560.html
- ↑ Wikipedia; Note: BDNF entry http://en.wikipedia.org/wiki/brain-derived_neurotrophic_factor
Database
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=627
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:627
- OMIM: https://mirror.omim.org/entry/113505
- OMIM: https://mirror.omim.org/entry/209880
- OMIM: https://mirror.omim.org/entry/610269
- UniProt: http://www.uniprot.org/uniprot/P23560.html