BDNF/NT-3 growth factors receptor; EC=2.7.10.1; neurotrophic tyrosine kinase receptor type 2; TrkB tyrosine kinase; GP145-TrkB; Trk-B (NTRK2 TRKB)
Jump to navigation
Jump to search
Function
- receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 & neurotrophin-4/5 but not nerve growth factor (NGF)
- role in development &/or maintenance of the nervous system
- tyrosine-protein kinase receptor
- substrates for the TRK receptors include: SHC1, PI-3 kinase, & PLC- gamma-1
- dynamic equilibrium between monomeric (low affinity) & dimeric (high affinity) structures
- binds SH2B2
- interacts with SQSTM1 & ARMS (putative)
- ligand-mediated auto-phosphorylation
Structure
- belongs to the protein kinase superfamily, Tyr protein kinase family, insulin receptor subfamily
- contains 2 Ig-like C2-type domains (immunoglobulin-like)
- contains 2 LRR repeats (leucine-rich repeats)
- contains 1 protein kinase domain
Compartment
membrane
Alternative splicing
named isoforms=3
Expression
- isoform TrkB is widely expressed, mainly in nervous tissue
- in the CNS, expression is observed in the cerebral cortex, hippocampus, thalamus, choroid plexus, granular layer of the cerebellum, brain stem, & spinal cord
- in the peripheral nervous system, it is expressed in many cranial ganglia, the ophthalmic nerve, the vestibular system, multiple facial structures, the submaxillary glands, & dorsal root ganglia
- isoform TrkB-T1 is expressed in multiple tissues, mainly in brain, pancreas, kidney & heart
- isoform TrkB-T-Shc is predominantly expressed in brain
More general terms
- tropomyosin receptor kinase (trk) proto-oncogene protein (NTRK)
- leucine-rich repeat-containing protein (LRRC)
- glycoprotein
- phosphoprotein
More specific terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q16620.html
- ↑ Klein R, Conway D, Parada LF, Barbacid M. The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain. Cell. 1990 May 18;61(4):647-56. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2160854