BDNF/NT-3 growth factors receptor; EC=2.7.10.1; neurotrophic tyrosine kinase receptor type 2; TrkB tyrosine kinase; GP145-TrkB; Trk-B (NTRK2 TRKB)

Function

• receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 & neurotrophin-4/5 but not nerve growth factor (NGF)
• role in development &/or maintenance of the nervous system
• tyrosine-protein kinase receptor
• substrates for the TRK receptors include: SHC1, PI-3 kinase, & PLC- gamma-1
• dynamic equilibrium between monomeric (low affinity) & dimeric (high affinity) structures
• binds SH2B2
• interacts with SQSTM1 & ARMS (putative)
• ligand-mediated auto-phosphorylation

Structure

• belongs to the protein kinase superfamily, Tyr protein kinase family, insulin receptor subfamily
• contains 2 Ig-like C2-type domains (immunoglobulin-like)
• contains 2 LRR repeats (leucine-rich repeats)
• contains 1 protein kinase domain

Compartment

membrane

Alternative splicing

named isoforms=3

Expression

• isoform TrkB is widely expressed, mainly in nervous tissue
• in the CNS, expression is observed in the cerebral cortex, hippocampus, thalamus, choroid plexus, granular layer of the cerebellum, brain stem, & spinal cord
• in the peripheral nervous system, it is expressed in many cranial ganglia, the ophthalmic nerve, the vestibular system, multiple facial structures, the submaxillary glands, & dorsal root ganglia
• isoform TrkB-T1 is expressed in multiple tissues, mainly in brain, pancreas, kidney & heart
• isoform TrkB-T-Shc is predominantly expressed in brain

More general terms

• tropomyosin receptor kinase (trk) proto-oncogene protein
• leucine-rich repeat-containing protein (LRRC)
• glycoprotein
• phosphoprotein

More specific terms

• trk B proto-oncogene protein (gp95trkB)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4915
• OMIM: https://mirror.omim.org/entry/600456
• UniProt: http://www.uniprot.org/uniprot/Q16620.html