neurotrophin-3; NT-3; HDNF; nerve growth factor 2; NGF-2; neurotrophic factor 3 (NTF3)
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Function
- neurotrophic for sensory neurons of nodose ganglion
- binds to gp145trkC, gp145trkB, gp140trk
- seems to promotes the survival of visceral & proprioceptive sensory neurons
- role in neuroplasticity, learning & memory[3]
Structure
belongs to the NGF-beta family
Compartment
Expression
- brain & peripheral tissues
- upregulated by fasting via switch from brain utilization of glucose to lactate[3]
- high-intensity exercise induces an increase in serum BDNF[3]
Polymorphism
- variant Glu-76 (frequently reported as Glu-63) was thought to be associated with severe forms of schizophrenia
- this seems not to be the case
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P20783.html
- ↑ Hohn A, Leibrock J, Bailey K, Barde YA. Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family. Nature. 1990 Mar 22;344(6264):339-41. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2314473
- ↑ 3.0 3.1 3.2 3.3 Gibbons TD et al Fasting for 20 h does not affect exercise-induced increases in circulating BDNF in humans. J Physiol. 2023 Jan 11. PMID: https://www.ncbi.nlm.nih.gov/pubmed/36631068