trk C protein; NT-3 growth factor receptor; neurotrophic tyrosine kinase receptor type 3; TrkC tyrosine kinase; GP145-TrkC; Trk-C (NTRK3, TRKC)
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Function
- receptor for neurotrophin-3 (NT-3)
- receptor tyrosine-kinase
- known substrates for the trk receptors are SHC1, PI-3 kinase, & PLCG1
- different isoforms do not have identical signaling properties
- exists in a dynamic equilibrium between monomeric (low affinity) & dimeric (high affinity) structures
- binds SH2B2
- interacts with SQSTM1 & ARMS (putative)
- ligand-mediated auto-phosphorylation
Structure
- belongs to the protein kinase superfamily, Tyr protein kinase family, insulin receptor subfamily
- contains 2 Ig-like C2-type domains (immunoglobulin-like)
- contains 2 LRR repeats (leucine-rich repeats)
- contains 1 protein kinase domain
Compartment
membrane
Alternative splicing
named isoforms=4
Expression
- widely expressed, mainly in the nervous tissue
- isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain
More general terms
- tropomyosin receptor kinase (trk) proto-oncogene protein
- leucine-rich repeat-containing protein (LRRC)
- glycoprotein
- phosphoprotein
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q16288.html
- ↑ Atlas of genetics & cytogenetics in oncology & haematology http://atlasgeneticsoncology.org/genes/NTRK3ID433.html
- ↑ Lamballe F, Klein R, Barbacid M. trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3. Cell. 1991 Sep 6;66(5):967-79. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1653651