ankyrin repeat-rich membrane spanning protein (kinase D-interacting substrate of 220 kD, ARMS, KIAA1250, KIDINS220)

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Function

promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism
provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation
may play role in regulating postsynaptic signal transduction through syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4
in cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation
may play a role in neurotrophin- & ephrin-mediated neuronal outgrowth & in axon guidance during neural development & in neuronal regeneration (putative)
modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway
interacts with NTRK1, NTRK2, NTRK3, ERKL & NGFR
can form a ternary complex with NGFR & NTRK1 & this complex is affected by the expression levels of ARMS
an increase in ARMS expression leads to a decreased association of NGFR & NTRK1
interacts with SNTA1 & SNTB2 & binds to their PDZ domains
interacts with EPHA4 & PRKD1 (putative)
tyrosine phosphorylated by NTRK1, NTRK2, EPHB2 & EPHA4
phosphorylation at Ser-918 is induced by phorbol ester
phosphorylation by NTRK2 is induced by BDNF & neurotrophin-4/5
phosphorylation by NTRK1 is induced by nerve growth factor (NGF) (putative)

membrane (putative)

overexpressed in melanoma & melanoma cell lines