ephrin type-A receptor 4; ephA4 receptor; tyrosine-protein kinase receptor SEK; receptor protein-tyrosine kinase HEK8; tyrosine-protein kinase TYRO1 (EPHA4, HEK8, SEK, TYRO1)

Function

• receptor for members of the ephrin-A family
• binds to ephrin-A1, ephrin-A4, ephrin-A5
• binds poorly to ephrin-A2, ephrin-A3.
• role in a signal transduction process involved in hindbrain development (putative)
• src family kinase, p59Fyn, through phospho-Tyr-602
• interacts with NGEF/ephexin-1 (putative)

Structure

• the protein kinase domain mediates interaction with NGEF/ephexin-1 (putative)
• belongs to the protein kinase superfamily, Tyr protein kinase family, Ephrin receptor subfamily
• contains 2 fibronectin F3 modules
• contains 1 protein kinase domain
• contains 1 SAM (sterile alpha motif) domain

Compartment

membrane

Expression

ubiquitous

More general terms

• ephA receptor

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2043
• OMIM: https://mirror.omim.org/entry/602188
• UniProt: http://www.uniprot.org/uniprot/P54764.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2043