ephrin-A5; EPH-related receptor tyrosine kinase ligand 7; LERK-7; AL-1 (EFNA5, EPLG7, LERK7)

Function

• may function actively to stimulate axon fasciculation
• induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor; this signaling event requires activity of Fyn tyrosine kinase
• binds to EPHB2 (putative)
• binds to the receptor tyrosine kinases EPHA2, EPHA3 & EPHB1

Structure

• belongs to the ephrin family

Compartment

• cell membrane; lipid-anchor, GPI-anchor
• membrane, caveola; lipid-anchor, GPI-anchor
• compartmentalized in discrete caveolae-like membrane microdomains

More general terms

• ephrin A or ephrin A ligand

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1946
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1946
• OMIM: https://mirror.omim.org/entry/601535
• UniProt: http://www.uniprot.org/uniprot/P52803.html