Ephrin type-A receptor 2; tyrosine-protein kinase receptor ECK; epithelial cell kinase (EPHA2, ECK, myk2, sek2)

Function

• receptor for members of the ephrin-A family
• binds to ephrin-A1, -A3, -A4 & -A5
• interacts with SLA (putative)
• interacts with INPPL1/SHIP2

Structure

• belongs to the protein kinase superfamily, Tyr protein kinase family, Ephrin receptor subfamily
• contains 2 fibronectin F3 modules
• contains 1 protein kinase domain
• contains 1 SAM (sterile alpha motif) domain

Compartment

membrane

Expression

• highly expressed in tissues containing many epithelial cells, i.e. skin, intestine, lung, & ovary

More general terms

• ephA receptor

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1969
• OMIM: https://mirror.omim.org/entry/176946
• UniProt: http://www.uniprot.org/uniprot/P29317.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1969