ephrin type-B receptor 1; tyrosine-protein kinase receptor EPH-2; NET; HEK6; ELK (EPHB1, EPHT2, NET)

Function

• receptor for members of the ephrin-B family, binds to ephrin-B1, ephrin-B2 & ephrin-B3
• may be involved in cell-cell interactions in the nervous system
• ligand-activated interacts with GRB2, GRB10 & NCK through their respective SH2 domains
• GRB10 SH2 domain binds EPHB1 through Tyr-928, while GRB2 binds residues within the catalytic domain
• NCK SH2 domain binds EPHB1 through Tyr-594
• interacts with PRKCABP (putative)

Structure

• belongs to the protein kinase superfamily, Tyr protein kinase family, Ephrin receptor subfamily
• contains 2 fibronectin F3 modules
• contains 1 protein kinase domain
• contains 1 SAM (sterile alpha motif) domain

Compartment

membrane

Alternative splicing

named isoforms=4

Expression

preferentially expressed in brain

More general terms

• ephB receptor
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2047
• OMIM: https://mirror.omim.org/entry/600600
• UniProt: http://www.uniprot.org/uniprot/P54762.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2047