ephrin-B1; EPH-related receptor tyrosine kinase ligand 2; LERK-2; ELK ligand; ELK-L; EFL-3 (EFNB1, EFL3, EPLG2, LERK2)
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Function
- binds to ephB1 receptor & ephA1 receptor
- ephrin B1 induces association of EphB2 receptors with the NR1 subunit (glutamate receptor zeta) of the NMDA receptor & causes these subunits to cluster[2]
- binds to, & induce the collapse of, commissural axons & growth cones in vitro
- may play a role in constraining the orientation of longitudinally projecting axons
- inducible phosphorylation of Tyr in the cytoplasmic domain (putative)
- interacts with GRIP1 & GRIP2
Structure
- belongs to the ephrin family
Compartment
- membrane; single-pass type 1 membrane protein
Expression
- heart, placenta, lung, liver, skeletal muscle, kidney, pancreas
- induced by TNF-alpha
Pathology
- defects in EFNB1 are a cause of craniofrontonasal syndrome
More general terms
References
- ↑ Eph Nomenclature Committee. Cell 90:403-4 1997
- ↑ 2.0 2.1 Ghosh A. Neurobiology. Learning more about NMDA receptor regulation. Science. 2002 Jan 18;295(5554):449-51. No abstract available. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11799227
- ↑ OMIM https://mirror.omim.org/entry/604597
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1947
- ↑ UniProt http://www.uniprot.org/uniprot/P98172.html
- ↑ GeneReviews http://www.ncbi.nlm.nih.gov/sites/genetests/lab/gene/EFNB1