ephrin B or ephrin B ligand
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Function
- presynaptic (axon terminal) transmembrane ligands for the ephB receptors
- binding of ephrin B to its ephB receptor results in phosphorylation of cytoplasmic Tyr in both the ephB receptor & ephrin B itself[2]
- since ephrin B does not have intrinsic kinase activity[3], phosphorylation by another kinase endogenous to the ligand espressing cell is necessary, possibly growth factor receptor such as PDGF receptor.
- proteins with PDZ domains interacting with ephrin B include syntenin, grip, pick 1, FAP-1 & PDZ-RGS
More general terms
More specific terms
- ephrin-B1; EPH-related receptor tyrosine kinase ligand 2; LERK-2; ELK ligand; ELK-L; EFL-3 (EFNB1, EFL3, EPLG2, LERK2)
- ephrin-B2; EPH-related receptor tyrosine kinase ligand 5; LERK-5; HTK ligand; HTK-L (EFNB2, EPLG5, HTKL, LERK5)
- ephrin-B3; EPH-related receptor tyrosine kinase ligand 8; LERK-8; EPH-related receptor transmembrane ligand ELK-L3 (EFNB3, EPLG8, LERK8)
References
- ↑ Eph Nomenclature Committee. Cell 90:403-4 1997
- ↑ 2.0 2.1 Ghosh A. Neurobiology. Learning more about NMDA receptor regulation. Science. 2002 Jan 18;295(5554):449-51. No abstract available. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11799227
- ↑ 3.0 3.1 Bruckner K, Pasquale EB, Klein R. Tyrosine phosphorylation of transmembrane ligands for Eph receptors. Science. 1997 Mar 14;275(5306):1640-3. PMID: https://www.ncbi.nlm.nih.gov/pubmed/9054357