protein tyrosine phosphatase 13, non-receptor type; Fas-associated phosphatase-1; FAP-1, protein-tyrosine phosphatase 1E (PTPN13, PNP1, PTP1E, PTPL1)

Function

• regulates negatively FAS-induced apoptosis & NGFR-mediated pro-apoptotic signaling
• interacts with TRIP6 & TNFRSF6 (Fas receptor) through its second PDZ domain
• interacts with the C-terminal SVP motif of NGFR through its 3rd PDZ domain
• interacts with the LIM domain of PDLIM4 through its 2nd & 4th PDZ domains
• binds PLEKHA1 & PLEKHA2 through its first PDZ domain
• interacts with BRD7 & ARHGAP29

Structure

• belongs to the protein-tyrosine phosphatase family non-receptor class subfamily
• contains 1 FERM domain
• contains 1 KIND domain
• contains 5 PDZ domain (DHR domain)s
• contains 1 tyrosine-protein phosphatase domain

Compartment

cytoplasm (putative)

Alternative splicing

named isoforms=4

Expression

• present in most tissues except liver & skeletal muscle
• most abundant in lung, kidney & fetal brain

Notes

may be due to a competing donnor splice site

More general terms

• tyrosine phosphatase, non-receptor type
• membrane protein

Additional terms

• CD95; Fas antigen; tumor necrosis factor receptor superfamily member 6; apo-1 antigen; apoptosis-mediating surface antigen FAS; FASLG receptor (FAS, APT1, FAS1, TNFRSF6)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5783
• OMIM: https://mirror.omim.org/entry/600267
• UniProt: http://www.uniprot.org/uniprot/Q12923.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5783