pleckstrin homology domain-containing family A member 1; PH domain-containing family A member 1; tandem PH domain-containing protein 1; TAPP-1 (PLEKHA1, TAPP1)

Function

• binds specifically to phosphatidylinositol-3,4-diphosphate (Ptdins(3,4)P2), but not to other phosphoinositides
• may recruit other proteins to the plasma membrane
• interacts with MPDZ & PTPN13

Structure

• binds to membranes enriched in Ptdins(3,4)P2 via the C-terminal PH domain
• contains 2 PH domains

Compartment

• cytoplasm
• plasma membrane
• nucleus
• locates to the plasma membrane after treatments that stimulate production of Ptdins(3,4)P2

Expression

• highly expressed in skeletal muscle, thymus, pancreas, placenta & lung
• detected at low levels in brain, heart, testis, ovary, peripheral blood leukocytes, spinal cord, thyroid, kidney, liver, small intestine & colon

More general terms

• pleckstrin homology domain containing family A (PLEKHA)
• phosphoprotein

Additional terms

• pleckstrin homology [PH] domain
• pleckstrin; platelet p47 protein (PLEK P47)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=59338
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:59338
• OMIM: https://mirror.omim.org/entry/607772
• UniProt: http://www.uniprot.org/uniprot/Q9HB21.html