thyroid receptor-interacting protein 6; TR-interacting protein 6; TRIP-6; Opa-interacting protein 1; OIP-1; Zyxin-related protein 1; ZRP-1 (TRIP6, OIP1)

Function

• relays signals from the cell surface to the nucleus to weaken adherens junction & promote actin cytoskeleton reorganization & cell invasiveness
• role in lysophosphatidic acid-induced cell adhesion & cell migration
• acts as a transcriptional coactivator for NF-kappa-B & JUN, & mediates the transrepression of these transcription factors
• induced by glucocorticoid receptor
• phosphorylation at Tyr-55 by SRC is required for enhancement of lysophosphatidic acid-induced cell migration
• Tyr-55 is dephosphorylated by PTPN13
• specifically interacts with the ligand binding domain of the thyroid hormone receptor in the presence of thyroid hormone
• interacts with PTPN13
• interacts with SVIL isoform 2
• interacts with LPAR2 but not other LPA receptors
• interacts with PRKAA2
• interacts with MAGI1
• interacts with SCRIB (putative)
• binds to S typhimurium protein sseI

Structure

• the LIM Zn+2-binding domains mediate interaction with LPAR2 & with S typhimurium protein sseI
• belongs to the zyxin/ajuba family
• contains 3 LIM Zn+2-binding domains

Compartment

• cytoplasm, cytoskeleton. cell junction, focal adhesion
• nucleus
• shuttles between nucleus & cytoplasm

Expression

• abundantly expressed in kidney, liver & lung
• lower expression in heart, placenta & pancreas
• expressed in colonic epithelial cells
• up-regulated in colon cancer

More general terms

• thyroid hormone receptor interacting protein (TRIP)
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7205
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7205
• OMIM: https://mirror.omim.org/entry/602933
• UniProt: http://www.uniprot.org/uniprot/Q15654.html