protein LAP4 (protein scribble homolog, hScrib, SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL)

Function

• role in polarization of epithelia ( putative)
• interacts through its PDZ domains with VANGL2
• interacts with UBE3A, HPV E6 & LPP
• ubiquitinated

Structure

• belongs to the LAP (LRR & PDZ) protein family
• contains 18 LRR repeats (leucine-rich repeats)
  • contains 4 PDZ domains (DHR domains)

Compartment

• cytoplasm, peripheral membrane
• localized to cell junctions

Alternative splicing

named isoforms=4

Pathology

• targeted for UBE3A-dependent multiubiquitination in the presence of high-risk HPV E6 proteins & degradated

More general terms

• phosphoprotein

More specific terms

• SCRIB overlapping open reading frame protein (oSCRIBB)

Database

• OMIM: https://mirror.omim.org/entry/607733
• UniProt: http://www.uniprot.org/uniprot/Q14160.html