lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma, LPP)

Function

• structural role at sites of cell adhesion in maintaining cell shape & motility
• role in signaling & activation of gene transcription (putative)
• role in signal transduction from cell adhesion sites to nucleus (putative)
• scaffold protein upon which protein complexes are assembled in cytoplasm & in nucleus (putative)
• interacts with VASP, with PDZ domains of SCRIB & with ACTN1/ alpha-actinin

Structure

• contains 3 LIM zinc-binding domains

Compartment

• nucleus, cytoplasm, cell junction, cell membrane (adhesion sites)
• shuttles between cytoplasm & nucleus
• sites of cell adhesion, cell-to-cell contact & focal adhesion
• mainly nuclear when fused with HMGA2/HMGIC & MLL

Expression

• expressed in a wide variety of tissues
• no or very low expression in brain & peripheral leukocytes

Pathology

• chromosomal translocation t(3;12)(q27-q28;q13-q15) involving LPP with HMGA2 is associated with lipomas
• chromosomal translocation t(3;12)(q28;q14) involving LPP with HMGA2 is associated with parosteal lipoma
• chromosomal translocation t(3;12)(q27-q28;q14-q15) involving LPP with HMGA2 is detected in pulmonary chondroid hamartomas
• chromosomal translocation t(3;11)(q28;q23) involving LPP with MLL is associated with acute monoblastic leukemia

More general terms

• adhesion protein
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/600700
• UniProt: http://www.uniprot.org/uniprot/Q93052.html