serine/threonine protein kinase 36; fused Drosophila homolog of FU; fused homolog (STK36 KIAA1278)

Function

• postnatal development
• homeostasis of cerebral spinal fluid
• ciliary function
• controls the activity of GLI1, GLI2, GLI3
• opposes effect of SUFU
• involved in hedgehog signaling
• binds gli protein
• interacts with SPAG16 & KIF27 (putative)

Cofactor: Mg+2

Structure

• belongs to the protein kinase superfamily, Ser/Thr protein kinase family
• contains 1 protein kinase domain

Alternative splicing

named isoforms=2

Expression

• expressed in adult testis
• expressed at low levels in most fetal tissues, adult ovaries

More general terms

• serine/threonine kinase

Additional terms

• suppressor of fused homolog; SUFUH (SUFU)

Database

• OMIM: https://mirror.omim.org/entry/607652
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=27148
• UniProt: http://www.uniprot.org/uniprot/Q9NRP7.html