gli-2 proto-oncogene protein; zinc finger protein GLI2; tax helper protein (GLI2, THP)

Function

• may play a role during embryogenesis
• binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the TRE-2S regulatory element that augments the Tax-dependent enhancer of human T-cell leukemia virus type 1
• implicated in the transduction of SHH signal

Structure

• belongs to the GLI C2H2-type Zn+2-finger protein family
• contains 5 C2H2-type Zn+2 fingers

Compartment

nucleus (putative)

Alternative splicing

named isoforms=4

Pathology

• defects in GLI2 are the cause of holoprosencephaly type 9

More general terms

• GLI-Krueppel family protein
• C2H2 type zinc finger protein

Database

• UniProt: http://www.uniprot.org/uniprot/P10070.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2736
• OMIM: https://mirror.omim.org/entry/165230
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2736