ubiquitin carboxyl-terminal hydrolase 6 (ubiquitin C terminal hydrolase TRE2, ubiquitin thioesterase 6, ubiquitin-specific-processing protease 6, deubiquitinating enzyme 6, proto-oncogene TRE-2, USP6, HRP1, TRE2)

Function

• ATP-independent isopeptidase activity
• cleaves at the C-terminus of the ubiquitin moiety
• in vitro, isoform 2, but not isoform 3, shows deubiquitinating activity

ubiquitin C-terminal thioester + H2O
        <-->
ubiquitin + a thiol

Structure

• belongs to the peptidase C19 family
• contains 1 Rab-GAP TBC domain

Alternative splicing

named isoforms=3

Expression

• testis specific
• expressed in various cancer cell lines

Pathology

involved in tumorigenesis

Genetics

USP6 gene only exists in the primate lineage

More general terms

• ubiquitin C-terminal hydrolase
• evolutionary divergent primate protein
• testis-specific protein

Additional terms

• ubiquitin (UBCEP2, UBB, UBC)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9098
• OMIM: https://mirror.omim.org/entry/604334
• UniProt: http://www.uniprot.org/uniprot/P35125.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9098