TBC/rab GTPase-activating (rab-GAP) domain (TBC/rab GAP domain, Tbc1, PTM)

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Introduction

~200 amino acid domain well conserved across species.

Contains 6 conserved motifs A to F.

A conserved Arg in motif is critical for full GAP activity.

The conserved Arg probably functions as a catalytic arginine finger analogous to that seen in ras & rhoGAPs.

The name TBC derives from the murine protein Tbc1. (see TBC1 domain family member)

The name PTM derives from 3 proteins known to contain it:

Appears to contain catalytic activities of yeast rab GAPs