gli-1 proto-oncogene protein; glioma associated transforming protein gli1; zinc finger protein GLI1 (GLI1, GLI)

Function

• may regulate the transcription of specific genes during normal development
• may play a role in craniofacial development & digital development, central nervous system development & gastrointestinal tract development
• mediates SHH signaling & thus cell proliferation & differentiation
• implicated in transduction of sonic hedgehog signalling

Structure

• belongs to the GLI C2H2-type Zn+2-finger protein family
• contains 5 C2H2-type Zn+2 fingers

Compartment

• cytoplasm, nucleus
• tethered in the cytoplasm by binding to SUFU
• activation & translocation to the nucleus is promoted by interaction with STK36

Expression

• testis, myometrium & fallopian tube

Pathology

• defects in GLI1 may be a cause of breast cancer
• amplified in glioblastoma cells

More general terms

• GLI-Krueppel family protein
• C2H2 type zinc finger protein

Database

• UniProt: http://www.uniprot.org/uniprot/P08151.html
• OMIM: https://mirror.omim.org/entry/165220
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2735