lysophosphatidic acid receptor Edg-4; LPA receptor 2; LPA-2 (EDG4, LPAR2, LPA2)

Function

• receptor for lysophosphatidic acid
• mediator of diverse cellular activities
• coupled to the Gi/Go G12/G13, & Gq families of heteromeric G proteins
• role in phospholipase C-beta (PLC-beta) signaling pathway
• interacts with SLC9A3R2/NHERF2 & PLCB3

Structure

• belongs to the G-protein coupled receptor 1 family

Compartment

membrane

Expression

• expressed in testes & peripheral blood leukocytes > pancreas, spleen, thymus, prostate
• little or no expression in heart, brain, placenta, lung, liver, skeletal muscle, kidney, ovary, small intestine, or colon

More general terms

• lysophosphatidic acid receptor (LPA-R)
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/605110
• UniProt: http://www.uniprot.org/uniprot/Q9HBW0.html