Na+/H+ exchange regulatory cofactor NHE-RF2; NHERF-2; NHE3 kinase A regulatory protein E3KARP; SRY-interacting protein 1; SIP-1; Na+-hydrogen exchanger regulatory factor 2; solute carrier family 9 isoform A3 regulatory factor 2; tyrosine kinase activator protein 1; TKA-1 (SLC9A3R2, NHERF2)

Function

• scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family & thereby helps to link them to the actin cytoskeleton & to regulate their surface expression
• necessary for cAMP-mediated phosphorylation & inhibition of SLC9A3
• may also act as scaffold protein in the nucleus
• homodimer, & heterodimer with SLC9A3R1
• binds PDZK1
• found in a complex with EZR, PODXL & SLC9A3R2 (putative)
• interacts (via the PDZ domains) with PODXL (via C-terminal PDZ-binding motif DTHL); interaction is detected in glomerular epithelium cells (putative)
• binds ADRB2, SLC9A3, P2RY1, P2YR2, SRY, RDX & LPAR2
• interacts with MCC & PODXL

Structure

• contains 2 PDZ domain (DHR domain)s

Compartment

• endomembrane system, peripheral membrane
• nucleus. apical cell membrane (putative)
• localizes with EZR & PODXL at the apical cell membrane of glomerular epithelium cells & their foot processes (putative)
• nuclear, in a punctate pattern

Alternative splicing

named isoforms=2

Expression

widely expressed

More general terms

• nuclear protein
• scaffold protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9351
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9351
• OMIM: https://mirror.omim.org/entry/606553
• UniProt: http://www.uniprot.org/uniprot/Q15599.html