radixin (RDX)

Function

• probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane
• phosphorylated by tyrosine-protein kinases (putative)
• binds SLC9A3R1. interacts with NHERF1, NHERF2, LAYN, MME/NEP & ICAM2 (putative)

Structure

• the N-terminal domain interacts with the C-terminal domain of LAYN
• an interdomain interaction between its N-terminal & C-terminal domains inhibits its ablilty to bind LAYN
• in the presence of acidic phospholipids, the interdomain interaction is inhibited & this enhances binding to LAYN (putative)
• contains 1 FERM domain

Compartment

• cell membrane
• peripheral membrane protein cytoplasmic side
• cytoplasm, cytoskeleton
• highly concentrated in the undercoat of the cell-to-cell adherens junction in interphase & the cleavage furrow in the mitotic phase

Pathology

• defects in RDX are the cause of autosomal recessive non-syndromic sensorineural deafness type 24

More general terms

• cytoskeletal protein

Database

• UniProt: http://www.uniprot.org/uniprot/P35241.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5962
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5962
• OMIM: https://mirror.omim.org/entry/179410
• OMIM: https://mirror.omim.org/entry/611022