mutated in colon cancer [MCC] anti-oncoprotein; colorectal mutant cancer protein; protein MCC (MCC)

Function

• candidate for the putative colorectal tumor suppressor gene located at 5q21
• postulated to bind to heterotrimeric Gq-protein inhibiting its interaction with receptor-catalyzed GDP/GTP exchange

Structure

belongs to the MCC family

Expression

expressed in a variety of tissues

Pathology

• probably involved in early stages of colorectal carcinoma in both sporadic & familial tumors

More general terms

• oligomerizing protein
• anti-oncoprotein (tumor suppressor protein)

Database

• UniProt: http://www.uniprot.org/uniprot/P23508.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4163
• OMIM: https://mirror.omim.org/entry/159350